In contrast to a similar structure of the estrogen receptor (165), only one molecule of SRC-3 is bound to the AR and the conformation of each NTD is proposed to be different based on visualizing antibodies recognizing the very N-terminus and AF1 regions resulting in an asymmetric appearance
196 When the Wnt/-catenin pathway is activated, it can reduce lipid ROS production in gastric cancer cells, and the -catenin/TCF4 transcription complex can directly bind to the GPX4 promoter region, enhancing its expression and thereby inhibiting cell ferroptosis
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As GR depends on the availability of NADPH, we propose that after prolonged conditions of higher temperature and humidity, progressive metabolic changes may be related to the depletion of this nucleotide
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